Which medication should the nurse clarify with the healthcare provider for a patient prescribed sildenafil?

Sildenafil, commonly known for treating erectile dysfunction and pulmonary hypertension, works by inhibiting phosphodiesterase type 5 (PDE5), leading to vasodilation and increased blood flow. When considering its use, it is crucial to be aware of potential interactions with other medications, especially those that can cause additional vasodilation.

Isosorbide, a medication used primarily for angina pectoris, acts as a nitrate which can also induce vasodilation. When administered in conjunction with sildenafil, there is a significant risk of hypotension due to the additive effects of both medications in lowering blood pressure. This combination can lead to severe side effects, such as dizziness, fainting, or even more serious cardiovascular complications.

In contrast, lisinopril, atorvastatin, and losartan do not carry the same risk of potentiating hypotension when used with sildenafil. Lisinopril and losartan are both antihypertensives, but they work through different mechanisms that do not cause the same immediate vasodilatory effects as nitrates. Atorvastatin is a medication that helps lower cholesterol levels and does not impact blood pressure in the same way. Therefore, the nurse should clarify the use of isosorbide with