Which medication requires pre-medication to mitigate infusion-related effects?

Amphotericin B is an antifungal medication known to potentially cause significant infusion-related reactions, which can include fever, chills, rigors, and hypotension. To minimize these side effects, healthcare providers often pre-medicate patients prior to administration of Amphotericin B. Common premedications may include corticosteroids, antipyretics (like acetaminophen), and antihistamines to help alleviate the uncomfortable symptoms that can occur during the infusion.

The other medications listed do not typically require pre-medication for infusion-related effects. For instance, Enoxaparin is an anticoagulant used to prevent blood clots, but it is administered via injection and does not cause infusion-related reactions. Dutasteride is a medication used to treat benign prostatic hyperplasia and does not involve infusion. Sevelamer is a phosphate binder used in patients with chronic kidney disease and is usually taken orally. As such, these medications are not associated with the same need for pre-medication.