Which instruction should a nurse provide to a patient using an MAO inhibitor for clinical depression?

The correct instruction for a patient using a monoamine oxidase inhibitor (MAOI) for clinical depression is to avoid chocolate and cheese. MAO inhibitors work by blocking the enzyme monoamine oxidase, which is responsible for breaking down certain neurotransmitters in the brain. They also inhibit the breakdown of tyramine, an amino acid that can lead to hypertensive crises when ingested in large amounts. Foods like cheese, particularly aged varieties, and chocolate contain high levels of tyramine. Consuming these can trigger severe hypertension and other dangerous side effects, which is why it's crucial for patients on MAOIs to follow dietary restrictions related to these foods.

The other options do not address critical interactions or safety concerns related to MAOIs. Taking frequent naps may be a general wellness suggestion but does not relate specifically to MAOI usage. Also, taking the medication with milk does not offer any specific benefit or mitigate risks associated with MAOIs. Similarly, walking without assistance is a safety concern not directly linked to MAOIs, as the medication does not primarily affect balance or coordination in that context.