What is the antidote for lorazepam toxicity?

Study for the NCLEX Archer Pharmacology Test. Prepare with a variety of multiple-choice questions, each with detailed hints and explanations. Get set to ace your exam!

Flumazenil is the correct antidote for lorazepam toxicity because it functions as a benzodiazepine antagonist. Lorazepam, which belongs to the benzodiazepine class, acts by enhancing the effects of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor, leading to increased sedative effects. In the case of an overdose or toxicity, flumazenil works by competitively inhibiting the binding of benzodiazepines to their receptors, effectively reversing the sedative effects and restoring normal neurological function.

This action is particularly useful in emergency settings when rapid reversal of sedation or respiratory depression is necessary. However, it's essential to use flumazenil cautiously, particularly in cases where there might be polydrug overdose, as it can also precipitate seizures in certain patients.

Other options are not appropriate for reversing lorazepam toxicity. Atropine, for instance, is used primarily as an anticholinergic agent for bradycardia and does not have any role in countering the effects of benzodiazepines. Activated charcoal is a treatment intervention for certain types of poisoning by reducing drug absorption but does not reverse the effects of an existing overdose. Similarly, N-ac

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