In managing an overdose of hydromorphone, which medication is most likely to be prescribed?

In the case of a hydromorphone overdose, naloxone is the most appropriate medication to prescribe. Naloxone is an opioid antagonist, meaning it works specifically to reverse the effects of opioids, including hydromorphone. When administered, naloxone competes for the same receptor sites as opioids in the central nervous system, effectively displacing the opioid molecules and reversing their effects. This is crucial in overdose situations, where respiratory depression and sedation can pose significant risks to the patient's safety.

Hydromorphone is a potent opioid analgesic, and its overdose can lead to life-threatening respiratory depression, decreased level of consciousness, and potentially fatal outcomes. Administration of naloxone rapidly restores normal breathing patterns and consciousness, making it a life-saving intervention in these cases.

Other medications listed do not have the necessary properties to effectively manage an opioid overdose. Sodium bicarbonate, while useful in treating certain types of metabolic acidosis, does not counteract the effects of opioid overdose. Flumazenil is a benzodiazepine antagonist but is not effective against opioid overdoses and could potentially exacerbate seizures in a poly-drug overdose scenario. Diphenhydramine, an antihistamine, does not have any role in reversing opioid